August 18, 2025

Medically Reviewed by Girish Desai, the Chief Pharmacist at Landys Chemist since 1982

Written by Rhysa Phommachanh Head of Digital Marketing

8 Proven and Promising Benefits of Fisetin

Fisetin is a natural plant compound (a flavonoid, meaning an antioxidant nutrient found in fruits and vegetables like strawberries, apples and onions). Research shows it may support healthy ageing, brain function, memory, inflammation, and metabolism. In animal studies, fisetin works as a senolytic, meaning it helps the body clear out old “zombie” cells that build up with age and contribute to ageing and decline. Early human trials are underway, but proven benefits in people are not confirmed yet. Current evidence is strongest in lab and animal research.

8 benefits of fisetin supplements

Quick Highlights of Fisetin Benefits

Healthy ageing / senolytic: Clears senescent “zombie” cells and extends lifespan in mice; robust preclinical signal.
Brain & memory: Preserves cognition and reduces Alzheimer related changes in animal models.
Antioxidant & anti-inflammatory: Broad protection across brain and other tissues in preclinical work.
Metabolic support: Improves insulin signalling and glucose handling in preclinical studies.
Cardiovascular (promising): Signals for vascular protection in models; human proof pending.
Skin / photoageing (promising): Antioxidant actions suggest UV and collagen support; human cosmetic trials limited.
Antimicrobial (promising): In vitro antiviral and antibacterial activity; clinical relevance unknown.
Human trials status: Early pilot and phase studies are ongoing; no definitive efficacy claims yet.

1) Fisetin for Healthy Ageing and Longevity

Fisetin is one of the best-studied natural senolytics. Late-life dosing in mice lowered senescent-cell burden, reduced age-related pathology, and extended median and maximum lifespan. This underpins its popularity in longevity circles, but these outcomes have not yet been replicated in humans.

2) Brain & memory support

In a study on Alzheimer’s-model mice, fisetin helped protect the brain, cut down harmful proteins, and improved memory test results. More studies are needed to see if the same applies to humans..

3) Antioxidant & anti-inflammatory defence

Reviews have found that Fisetin may protect cells from oxidative stress and calm inflammation. These two processes are linked to ageing, brain decline, and chronic illnesses.

4) Metabolic Health

Research suggests fisetin can improve insulin signalling and blood sugar control in animal studies. It could be relevant for type 2 diabetes, but human evidence is still very limited.

5) Cardiovascular support (promising)

Emerging reviews suggest fisetin might help blood vessels stay healthy and reduce stiffness. These findings are early and not yet tested in people.

6) Skin & Photoageing (Promising)

Because fisetin is a strong antioxidant, it may help reduce skin damage from UV rays and protect collagen. Current data is preclinical only - not yet in human cosmetic trials.

7) Antimicrobial Action (Early Stage)

Lab studies show fisetin has antiviral and antibacterial effects, but clinical utility has not been established.

8) Human Trials: What We Know

Fisetin is now being tested in early human studies to check safety, absorption, and effects on ageing markers. Results are not yet published, so fisetin should be seen as experimental in humans.

Safety & Practical Advice

Proven in humans? Not yet. Most benefits are from lab and animal studies.
Who might try it? Adults interested in healthy ageing.
Important: Fisetin may interact with medicines. Always speak to a GP or pharmacist before use.

Natural Sources of Fisetin

Strawberries: one of the richest natural sources
Apples: contain moderate amounts
Onions: especially red onions
Grapes: including skin and seeds
Cucumbers: small amounts but widely consumes

Summary

Fisetin is emerging as one of the most exciting natural compounds for healthy ageing, brain support, and overall wellness. Research in animals suggests powerful anti-ageing, anti-inflammatory, and neuroprotective effects - with human trials now awaited to confirm these benefits.

If you’re curious about adding fisetin to your routine, explore our range of trsuted fisetin supplements for convenient daily support.