Anti-Ageing Skincare: Avène Hyaluron Activ B3

What Is Avene Hyaluron Activ B3?

Avène Hyaluron Activ B3 is the latest skincare range for ageing skin that focuses on combating the cause and minimising visible signs of ageing. The ageing skin market is huge and there are numerous products that help reduce the appearance of fine lines and wrinkles, and loss of elasticity. You might be wondering “So what makes this anti-ageing skincare range any different from the others?,” the answer goes back to what inspired the whole range, and that is cellular senescence.

avene hyaluron acitv b3 range

What Is Cellular Senescence?

Cellular senescence consists of cells becoming old because of external factors such as pollution, smoking, and sun exposure which accelerates the skins ageing process.

Cellular Senescence is contagious:

When our skin cells are damaged, they become senescent, often referred to as “zombie cells” as they refuse to die and begin to emit what is known as senescence messaging secretom (SMS). SMS contaminates surrounding healthy cells, accelerating skin ageing causing fine lines, wrinkles, loss of elasticity, dullness, uneven skin tone, pigmentation, and more.

Avène Hyaluron Activ B3, thanks to a unique combination of active ingredients specifically focuses on preventing cellular senescence and the acceleration of ageing caused by senescent skin cells.

How The Hyaluron Activ B3 Anti-Ageing Formula Works:

Thanks to a unique combination of active ingredients, the Avène Hyaluron Activ B3 range for ageing skin works to reverse cellular senescence by turning these senescent cells into stem cells which can then regenerate them to become healthy again. The range was developed with Pr. Jean-Marc Lemaitre, a world-leading expert specialised in regenerative medicine and biotherapy who found that senescent stem cells are able to regenerate into fully rejuvenated cells with his team.

With these findings, Pr. Lemaitre and Avène have come together to apply these findings to the skin with the use of innovative skincare. Thanks to its unique formula, the Hyaluron Activ B3 range helps prevents cellular senescence by stopping senescent cells from communicating with other cells and spreading. This activity is referred to as senomorphic activity.

Hyaluron Activ B3 Results:

Hyaluron Activ B3 is formulated with specific ingredients that directly act on cellular senescence and have proven results on visible signs of ageing. The skin looks smoother, re-plumped, and radiant. After 15 days, the skin looks regenerated, firmer and wrinkles appear reduced.*

*self-evaluation, 71 users, 1 application per day. 

avene hyaluron activ b3 lifestyle image

Key Ingredients in the Hyaluron Activ B3 Range:

Avène’s Hyaluron Activ B3 range contains Hyaluronic Acid, Niacinamide, Haritaki Extract, Dextran Sulphate, and Retinaldehyde which vary between each product. Here are the key benefits of each of these ingredients:

Low and High Molecular Hyaluronic Acid:

Hyaluronic Acid (HA) is a key component in keeping our skin hydrated and plump. When our skin lacks HA, it begins to show signs of fine lines and wrinkles. The Hyaluron Activ B3 range contains HA at both low and high molecular weights which not only hydrates the surface of our skin but also penetrates the deeper layers of our skin (epidermis).

The Hyaluronic Acid market is extensive, but there are many low-quality products that only contain high molecular weight HA which can only sit on the surface of the skin. If you wish to reap the full benefits of HA, investing in high-quality skincare like the Hyaluron Activ B3 range is the best way to see visible results.

Highly Concentrated Niacinamide (vitamin B3):

Niacinamide, also known as vitamin B3, is a potent ingredient that helps improve the skin's barrier function, reduce moisture loss, reduce inflammation, reduce the appearance of fine lines and wrinkles, improve skin elasticity and texture, and reduce hyperpigmentation. This active ingredient is a powerful anti-ageing saviour when concentrated. 6% Niacinamide has been found to increase cell longevity by 50%.


Retinaldehyde, also known as vitamin A, is a gold standard ingredient for anti-ageing uses. It contributes to the firmness of the epidermis which boosts collagen production, elastic, and Hyaluronic Acid.

Dextran Sulphate:

Dextran Sulphate acts as a decongestant ingredient with anti-inflammatory properties. It is specifically useful for reducing puffiness around the eye area.

Haritaki Extract:

Haritaki Extract (also known as Chebula) helps to prevent oxidative stress from affecting our skin to prolong the life and health of our skin cells and protect the skin’s natural balance of Hyaluronic Acid.

The Benefits of The Hyaluron Activ B3 Range:

Avène Hyaluron Activ B3 Cellular Renewal Day Cream:

The Cell Renewal Cream is concentrated with 1.5% Hyaluronic Acid and 6% Niacinamide. This daily moisturiser helps to restore and protect the skin for firmer, radiant skin. Its protective formula significantly reduces cellular senescence (a key cause of ageing skin).

Avène Hyaluron Activ B3 Concentrated Plumping Serum:

The Hyaluron Activ B3 serum is highly concentrated with 1.5% Hyaluronic Acid and 6% Niacinamide (which increases cell longevity by 50%). This high strength plumping serum immediately smooths the skin and corrects the appearance of wrinkles. It penetrates deep into the epidermis layer of the skin where it can effectively restore the skin to reduce wrinkles, fine lines, and strengthen the skin’s elasticity.

Avène Hyaluron Activ Triple Correction Eye Cream:

The Triple Correction Eye Cream is slightly tined to instantly brighten the eye area. This formula contains Niacinamide, Hyaluronic Acid, Haritaki Extract and Dextran Sulphate to depuff the eye contour area, smooth visible wrinkles and visibly boost the radiance around the eye contour to tackle dark circles.

Avène Hyaluron Activ Multi-Intensive Night Cream:

Hyaluron Activ Multi-Intensive Night Cream is aimed for those concerned about their wrinkles and fine lines as well as people experiencing a loss of firmness and elasticity and dull skin. This optimal restoring moisturiser contains 4 of the active ingredients: Retinaldehyde, Niacinamide, Hyaluronic Acid and Haritaki which work best at night as this is when the skin begins to regenerate.

Who Is Hyaluron Activ B3 suitable for?

This Avène Hyaluron Activ B3 range is suitable for all skin types, including sensitive skin. It is suitable for anti-ageing skin concerns but can also be highly beneficial to those who want to protect their skin from cellular senescence damage earlier. The versatile active ingredients like Hyaluronic Acid and Niacinamide mean that it can also help with dryness, hyperpigmentation, controlling excess sebum production, and more. These products are all fragrance-free.

avene anti ageing skincare


By Rhysa Phommachanh, BA (hons) Specialist Skincare and Media Make up