Benefits of hyaluronic acid and niacinamide together

Benefits of using Hyaluronic Acid and Niacinamide Together


When incorporating both Hyaluronic Acid and Niacinamide together, you can expect to create one of the best anti-aging skincare routines, focusing on hydration, firmness, elasticity, and overall skin health and appearance.

In this blog, we explain the benefits of both Hyaluronic Acid and Niacinamide when used as an anti-ageing solution. We also explore Avène's Hyaluron Activ B3 line, which expertly blends the potent properties of hyaluronic acid and niacinamide within their transformative skincare formulations.

What is Hyaluronic Acid

Hyaluronic Acid (HA) is a naturally occurring molecule in the skin that plays a crucial role in maintaining its moisture and youthful appearance. It is a water-based compound with humectant properties that possess an exceptional ability to retain water, holding up to 1000 times its weight in moisture, making it a sought-after ingredient in skincare products.

Benefits of using Hyaluronic Acid

  • Moisturises and hydrates the skin: Hyaluronic Acid retains moisture, providing intense and immediate hydration to the skin. It helps to combat dry patches and flakiness, associated with dry and dehydrated skin types, having a transformative effect on skin texture.
  • Plumps and Firms the skin: Hyaluronic Acid reduces signs of ageing as it plumps and firms the skin by attracting and retaining moisture, resulting in a smoother and more supple complexion. This hydration-driven effect helps reduce the appearance of fine lines and wrinkles, promoting a youthful and revitalised appearance, and enhancing the skins elasticity.
  • Calms and soothes the skin: When applied to the skin, hyaluronic acid forms a hydrating barrier that helps to soothe inflammation and irritations. By promoting well-hydrated and supple skin, hyaluronic acid contributes to reducing redness, dryness, and overall signs of sensitivity.
  • Can boost collagen production: Hyaluronic acid supports collagen production by creating an environment beneficial for collagen synthesis. Through its moisture-retaining properties, hyaluronic acid prevents collagen fibers from becoming brittle whilst supporting their flexibility, aiding in the skin's overall suppleness.
  • Helps to repair the skin barrier: Hyaluronic acid’s humectant support the skin's natural healing processes, helping to alleviate dryness, reduce irritation, and fortify the barrier against external stressors to improve skin barrier function.

What is Niacinamide?

Niacinamide, also known as vitamin B3 or nicotinamide, is a water-soluble nutrient that belongs to the vitamin B complex group. It plays a crucial role in supporting various bodily functions, including metabolism, cell communication, and DNA repair.

Benefits of using Niacinamide:

  1. Regulates Sebum Production: Niacinamide helps to balance oil production in the skin, making it beneficial for both oily and acne-prone skin. It helps control excess sebum production, which can lead to fewer breakouts and a more matte appearance. The sebum regulation also helps to reduce enlarged pores.
  2. Anti-Aging Effects: Niacinamide may contribute to the production of elastin, which is a  protein responsible for maintaining skin's elasticity and firmness. Higher levels of niacinamide in skincare products can contribute to reducing signs of ageing such as fine lines and wrinkles, promoting a more youthful appearance over time.
  3. Improves Skin Barrier Function: Niacinamide strengthens the skin's protective barrier by boosting the production of ceramides, a type of lipid that helps maintain moisture and prevent water loss. A stronger skin barrier can lead to better hydration and less sensitivity.
  4. Reduces Hyperpigmentation: Niacinamide has been shown to inhibit the transfer of pigment within the skin cells, leading to a reduction in the appearance of dark spots, sunspots, and uneven skin tone. It's a useful ingredient for addressing hyperpigmentation concerns.

Benefits of using Hyaluronic Acid and Niacinamide Together

Combining both niacinamide and hyaluronic acid together will help to combat a range of skincare concerns including signs of ageing like fine lines and wrinkles. Hyaluronic acid maintains optimal moisture levels, preventing dehydration-induced wrinkles, whilst niacinamide strengthens the skin's protective barrier and supports collagen production, diminishing the appearance of fine lines. When these two ingredients are combined in a well-formulated product, their effects are amplified, yielding a more comprehensive anti-ageing solution.

How To Find The Best Hyaluronic acid and Niacinamide Skincare Products

There are a two key elements to consider when searching for an effective skincare routine with hyaluronic acid and niacinamide including:

1. Molecular Weight of Hyaluronic Acid:

Many hyaluronic products on the market contain high molecular weight HA which tends to work on the surface of the skin, therefore it is important to search for skincare products that combine low molecular weight hyaluronic acid like the Avène's Hyaluron Activ range. Studies prove that low molecular Hyaluronic acid which is able to penetrate into the deeper layer (stratum corneum) of the skin.

2. Concentration of Niacinamide:

Studies have found that a concentration of at least 5% niacinamide is needed to make notable changes to the skins surface to reduce visible signs of ageing, therefore it is important to look for a potent formula with a higher percentage. The Avène's Hyaluron Activ range incorporates 6% niacinamide into their formulas.

Avene Hyaluron Activ B3: The Perfect Hyaluronic Acid and Niacinamide Duo

Avène's Hyaluron Activ B3 harnesses the strengths of low and high molecular weight Hyaluronic Acid with a high concentration of Niacinamide, leading in a new era of skin vitality. It was developed in collaboration with Pr. Jean-Marc Lemaitre, a distinguished global expert in regenerative medicine and biotherapy. Pr. Jean-Marc Lemaitre and his team discovered that senescent stem cells possess the remarkable capability to transform into completely revitalised cells through regeneration.

With this discovery, Pr. Lemaitre and Avène joined forces to create the exceptional formulas of the Hyaluron Activ B3 range to serve as a shield against cellular senescence, effectively interrupting the communication and dissemination of senescent cells to other cells (known as senomorphic activity) with the range's unique formulation including 1.5% hyaluronic acid and 6% niacinamide along with other key ingredients.

The Key benefits of Avene Hyaluron Activ B3

  • Hydration from Low and High Molecular Hyaluronic acid: The range's innovative blend deeply hydrates the skin, with its blend of  high and low molecular weight Hyaluronic Acid that penetrates the deeper layers for long-lasting moisture.
  • Potent Niacinamide concentration: With a potent 6% concentration of Niacinamide, the range elevates skin health by regulating sebum production, strengthening the skin barrier, and reducing hyperpigmentation.
  • Anti-Ageing Resilience: The combined power of Hyaluronic Acid and Niacinamide in the range combats fine lines, wrinkles, and loss of elasticity, offering a comprehensive approach to ageless, radiant skin.
  • Boosts anti-ageing power with Retinaldehyde: Retinal, a derivative of vitamin A, enhances the anti-aging effects of niacinamide and hyaluronic acid by promoting skin cell turnover, reducing the appearance of fine lines, and improving overall texture. It complements their benefits by encouraging collagen production and optimising moisture retention.
  • Cellular Rejuvenation: Leveraging regenerative medicine and biotherapy insights, the Avène Hyaluron Activ B3 range encourages senescent cells to transform into rejuvenated cells, resulting in a more youthful appearance.

Recommended hyaluronic acid and niacinamide skincare routine

  1. After cleansing both day and night, treat your skin with Avène Hyaluron Activ B3 Plumping Serum. This  concentrated plumping serum with 1.5% high and low molecular hyaluronic acid and 6% niacinamide helps to immediately smooth the skin and correct the appearance of wrinkles.

  1. Apply the Avène Hyaluron Activ B3 Triple Correction Eye Cream:  this eye cream has a powerful formula containing Niacinamide, Hyaluronic Acid, Haritaki Extract and Dextran Sulfate. This eye cream helps to visibly depuff the eye contour area, smooths visible wrinkles and visibly boosts the radiance of the eyes.

  1. In the morning, moisturise with Avène Hyaluron Activ B3 Cell Renewal Day Cream. This potent formula is concentrated in Hyaluronic Acid and Niacinamide. It helps to restore the skin for an instant firmer, radiant, and plumped appearance. 

  1. In the evening, moisturise with Avène Hyaluron Activ B3 Multi-Intensive Night Cream. This regenerating night cream is an optimal restoring skincare product containing 4 active ingredients: Retinal, Niacinamide, Hyaluronic Acid and Haritaki. It is aimed for those concerned about their wrinkles and fine lines as well as people experiencing a loss of firmness and elasticity and dull skin. 


  • Hyaluronic acid and niacinamide are both powerful skincare ingredients that can tackle a range of skincare concerns including ageing, pigmentation, texture, and dryness.
  • For a hyaluronic acid and niacinamide skincare product to be effective towards ageing concerns, the molecular weight of hyaluronic acid and concentration of niacinamide are important factors to consider.
  • The Avène Hyaluron Activ B3 range contains is an exceptional formulation of both Hyaluronic acid and niacinamide along with other ingredients to create a powerful anti-ageing solution which also tackles a range of other skincare concerns including dryness.

By Rhysa Phommachanh BA (hons) Specialist Hair, Skincare, and Media Makeup